I'm going with You Really Got Me. I never cared for the original, it doesn't excite me in the least bit (other than improvised jams during it), it's been massively overplayed since Van Halen I came out, and I truly would not shed a tear if I never heard it again.
I posted a poll because those other songs are ones that have frequently come up in other tour discussions, and I figure they will get the bulk of the votes.