Department of State
Secretary Hillary Rodham Clinton
Hillary's actually done OK, but she said that she wouldn't do more than one term. Joe Biden's already got a gig, so he's out of consideration. Some have suggested Judas IsKerryot, but that's a bad idea, because the last time they had a "special election" to fill a Senate seat in that state, they got a naked tabloid model. And given that Elizabeth Warren kicked his ass last night, he might try to run for Kerry's seat.
Department of the Treasury
Secretary Timothy F. Geithner
No question that Timmy the Elf needs to be the first one out the door. Robert Reich or Paul Krugman should replace him
Department of Defense
Secretary Leon E. Panetta
I don't really have a candidate in mind here, but the revolving door between the military and the CIA really needs to stop.
Department of Justice
Attorney General Eric H. Holder, Jr.
Bring in John Edwards or Elliot Spitzer. Hell, I'll send up a legion of succubi so nobody has to worry about "bimbo eruptions" turning up in the tabloids.
Department of the Interior
Secretary Kenneth L. Salazar
Lose this turd, bring in Bobby Kennedy Jr.
Department of Agriculture
Secretary Thomas J. Vilsack
Dump VilSuck and anybody else with Monsanto connections. Replace him with Willie Nelson.
Department of Commerce
Acting Secretary Rebecca Blank
I say we bring in the guy from Tesla, Elon Musk, except I wouldn't want to take him away from that company. Or his space company, for that matter
Department of Labor
Secretary Hilda L. Solis
She can stay
Department of Health and Human Services
Secretary Kathleen Sebelius
Replace her with Dr. Howard Dean. YEEEAAARRRGGGHHH
Department of Education
Secretary Arne Duncan
Replace him with someone who doesn't have their head up their ass with trying to privatize public education
Department of Housing and Urban Development
Secretary Shaun L.S. Donovan
Don't have any suggestions here
Department of Transportation
Secretary Ray LaHood
Bring in somebody who can get some 21st century infrastructure going.
Department of Energy
Secretary Steven Chu
Ditto
Department of Veterans Affairs
Secretary Eric K. Shinseki
He can probably stick around. If he doesn't want to, bring in Max Cleland.
Department of Homeland Security
Secretary Janet A. Napolitano
Eliminate this ridiculous fascist named bureaucracy altogether.